Venous Mechanical Properties After Arteriovenous Fistulae in Mice.

ABSTRACT:

Background

An arteriovenous fistula (AVF) exposes the outflow vein to arterial magnitudes and frequencies of blood pressure and flow, triggering molecular pathways that result in venous remodeling and AVF maturation. It is unknown, however, how venous remodeling, that is lumen dilation and wall thickening, affects venous mechanical properties. We hypothesized that a fistula is more compliant compared with a vein because of altered contributions of collagen and elastin to the mechanical properties.

Methods

Ephb4^+/- and littermate wild-type (WT) male mice were treated with sham surgery or needle puncture to create an abdominal aortocaval fistulae. The thoracic inferior vena cava was harvested 3 wk postoperatively for mechanical testing and histological analyses of c

SUBMITTER: Brownson KE 

PROVIDER: S-EPMC7054128 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature