Association between a cognitive screening test and severe chemotherapy toxicity in older adults with cancer.

ABSTRACT:

Introduction

Cognitive impairment (CI) increases chemotherapy toxicity risk with need to understand this association utilizing publicly available short screening tools. We evaluated this utilizing a lower threshold on a short screening tool in older adults with cancer.

Materials and methods

We analyzed data from the Cancer and Aging Research Group (CARG) Chemotherapy Toxicity Risk tool (CARG score) development and validation cohorts (n = 703), which recruited adults age ≥ 65 with cancer from academic centers. Cognition was evaluated with the Blessed Orientation-Memory-Concentration test (BOMC). Patients with BOMC score ≥ 11 were excluded. Utilizing cut-points for older adults, we considered moderate BOMC scores (5-10) as potential CI. Logistic regression was used for analysi

SUBMITTER: Jayani RV 

PROVIDER: S-EPMC7054133 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature