Modeling inter-sex and inter-individual variability in response to chronopharmacological administration of synthetic glucocorticoids.

ABSTRACT: Endogenous glucocorticoids have diverse physiological effects and are important regulators of metabolism, immunity, cardiovascular function, musculoskeletal health and central nervous system activity. Synthetic glucocorticoids have received widespread attention for their potent anti-inflammatory activity and have become an important class of drugs used to augment endogenous glucocorticoid activity for the treatment of a host of chronic inflammatory conditions. Chronic use of synthetic glucocorticoids is associated with a number of adverse effects as a result of the persistent dysregulation of glucocorticoid sensitive pathways. A failure to consider the pronounced circadian rhythmicity of endogenous glucocorticoids can result in either supraphysiological glucocorticoid exposure or severe su

SUBMITTER: Scherholz ML 

PROVIDER: S-EPMC7054177 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature