Age-Related Decreases in Interhemispheric Resting-State Functional Connectivity and Their Relationship With Executive Function.

ABSTRACT: Age-related alterations of functional brain networks contribute to cognitive decline. Current theories indicate that age-related intrinsic brain functional reorganization may be a critical marker of cognitive aging. Yet, little is known about how intrinsic interhemispheric functional connectivity changes with age in adults, and how this relates to critical executive functions. To address this, we examined voxel-mirrored homotopic connectivity (VMHC), a metric that quantifies interhemispheric communication, in 93 healthy volunteers (age range: 19-85) with executive function assessment using the Delis-Kaplan Executive Function System (D-KEFS) scales. Resting functional MRI data were analyzed to assess VMHC, and then a multiple linear regression model was employed to evaluate the relationship

SUBMITTER: Zhao J 

PROVIDER: S-EPMC7054233 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature