The neurochemical substrates of habitual and goal-directed control.

ABSTRACT: Our daily decisions are governed by the arbitration between goal-directed and habitual strategies. However, the neurochemical basis of this arbitration is unclear. We assessed the contribution of dopaminergic, serotonergic, and opioidergic systems to this balance across reward and loss domains. Thirty-nine participants (17 healthy controls, 15 patients with pathological gambling, and 7 with binge eating disorder) underwent positron emission tomography (PET) imaging with [¹⁸F]FDOPA, [¹¹C]MADAM and [¹¹C]carfentanil to assess presynaptic dopamine, and serotonin transporter and mu-opioid receptor binding potential. Separately, participants completed a modified two-step task, which quantifies the degree to which decision-making is influenced by goal-directed or

SUBMITTER: Voon V 

PROVIDER: S-EPMC7054261 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature