Constituents and Metabolites of a French Oak Wood Extract (Robuvit^®) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy.

ABSTRACT: Ellagitannins are signature constituents of oak wood and their consumption has been associated with various health benefits. In vivo, they undergo metabolic degradation including gut microbial metabolism yielding urolithins. Only limited data is available about compounds being present in blood after intake of an extract from French oak wood, Robuvit^®. In the course of a randomized, double-blind, controlled clinical investigation, 66 patients undergoing hysterectomy received placebo or 300 mg Robuvit^® per day before and over 8 weeks after surgery. Serum and blood cell samples were analyzed by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The number of urolithin producers and the urolithin levels increased after intake of

SUBMITTER: Volpp L 

PROVIDER: S-EPMC7054277 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature