Comparison of the Safety and Tolerance Profile of Micafungin with that of Other Echinocandins and Azoles in Patients with Pre-existing Child-Pugh B or C Liver Disease: A Case-Control Retrospective Study.

ABSTRACT: INTRODUCTION:To assess the association between exposure to micafungin, other echinocandins, or azoles and the development of short-term liver injury (STLI) or long-term liver injury (LTLI) in patients with Child-Pugh B or C liver disease. METHODS:Multicenter case-control study of patients with Child-Pugh B or C liver disease who received antifungals (AF) for ≥ 72 h (May 2009-May 2015) in six Spanish and Italian hospitals. All micafungin patients were randomly matched with one patient who received another echinocandin and with one patient who received azole treatment. Primary outcome was development of STLI or LTLI (development of any type of liver tumor during the follow-up period). RESULTS:Of 2335 patients with chronic liver disease admitted to the six centers, 20 (0.85%) were found to ha

SUBMITTER: Vena A 

PROVIDER: S-EPMC7054556 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature