Ontology highlight
ABSTRACT:
SUBMITTER: Ursino GM
PROVIDER: S-EPMC7054684 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
EMBO reports 20200218 3
Dysregulation of lipid homeostasis is intimately associated with defects in insulin secretion, a key feature of type 2 diabetes. Here, we explore the role of the putative lipid transporter ABCA12 in regulating insulin secretion from β-cells. Mice with β-cell-specific deletion of Abca12 display impaired glucose-stimulated insulin secretion and eventual islet inflammation and β-cell death. ABCA12's action in the pancreas is independent of changes in the abundance of two other cholesterol transport ...[more]