Cardiac Nestin⁺ Mesenchymal Stromal Cells Enhance Healing of Ischemic Heart through Periostin-Mediated M2 Macrophage Polarization.

ABSTRACT: Mesenchymal stromal cells (MSCs) show potential for treating cardiovascular diseases, but their therapeutic efficacy exhibits significant heterogeneity depending on the tissue of origin. This study sought to identify an optimal source of MSCs for cardiovascular disease therapy. We demonstrated that Nestin was a suitable marker for cardiac MSCs (Nes⁺cMSCs), which were identified by their self-renewal ability, tri-lineage differentiation potential, and expression of MSC markers. Furthermore, compared with bone marrow-derived MSCs (Nes⁺bmMSCs) or saline-treated myocardial infarction (MI) controls, intramyocardial injection of Nes⁺cMSCs significantly improved cardiac function and decreased infarct size after acute MI (AMI) through paracrine actions, rather than

SUBMITTER: Liao Y 

PROVIDER: S-EPMC7054724 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature