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Remembrances of parental rejection are associated with loneliness as mediated by psychological maladjustment in young Bangladeshi men but not women.

ABSTRACT: Loneliness is a significant public health issue that affects young adults. This investigation drew from interpersonal acceptance-rejection theory to understand how remembrances of parental rejection contributed to psychological maladjustment and loneliness in Bangladeshi college students (N = 300; 50% female). Students reported their remembrances of mothers' and fathers' acceptance-rejection, their current psychological maladjustment, and loneliness. Remembrances of rejection by parents in childhood were associated with psychological maladjustment (hostility/aggression, negative self-esteem, negative self-adequacy, emotional unresponsiveness, emotional instability, and negative worldview) for young adult men and women. Psychological maladjustment, in turn, was associated with feelings of loneliness in young adulthood for young men, but not women. Remembrances of parental rejection were also associated with greater hostility and aggression over and above general psychological functioning among both men and women. Findings are discussed in the context of different social and structural features of young adulthood for women and men in Bangladesh.

SUBMITTER: Putnick DL

PROVIDER: S-EPMC7054894 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Remembrances of parental rejection are associated with loneliness as mediated by psychological maladjustment in young Bangladeshi men but not women.

Putnick Diane L DL Uddin Muhammad Kamal MK Rohner Ronald P RP Singha Bipasha B Shahnaz Ishrat I

International journal of psychology : Journal international de psychologie 20190726 3

Loneliness is a significant public health issue that affects young adults. This investigation drew from interpersonal acceptance-rejection theory to understand how remembrances of parental rejection contributed to psychological maladjustment and loneliness in Bangladeshi college students (N = 300; 50% female). Students reported their remembrances of mothers' and fathers' acceptance-rejection, their current psychological maladjustment, and loneliness. Remembrances of rejection by parents in child ...[more]

PMID: 31347709

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Project description:BackgroundThe in-vivo regulation of vascular conductance (VC) is a continuous balance between endothelial vasodilation and sympathetic vasoconstriction. Although women may report blunted sympathetic vasoconstriction along with higher endothelial vasodilation than men, it is currently unknown whether the interaction between vasoconstriction and vasodilation leads to different regulation of VC between sexes. This study assessed sex differences in sympathetic-mediated blunting of endothelial vasodilation after a brief period of ischemia and whether any restriction of vasodilation blunts tissue blood flow (BF) and re-oxygenation.Methods13 young women and 12 young men underwent two 5-min forearm circulatory occlusions followed by reperfusion, one in basal conditions and the other during cold pressor test-induced sympathetic activation (SYMP). Brachial artery diameter and BF, mean arterial pressure, total peripheral resistance (TPR), and thenar eminence oxygenation were collected. Percent changes normalized to baseline values of forearm VC, brachial artery BF and flow-mediated dilation (FMD), TPR, and hand oxygenation after circulatory reperfusion were calculated.ResultsTPR increased during SYMP in men (p = 0.019) but not in women (p = 0.967). Women showed a greater brachial artery FMD than men (p = 0.004) at rest, but sex differences disappeared after normalization to shear rate and baseline diameter (p > 0.11). The percent increases from baseline of peak and average forearm VC after circulatory reperfusion did not differ between sexes in basal conditions (p > 0.98) or during SYMP (p > 0.97), and were restrained by SYMP similarly in both sexes (p < 0.003) without impairing the hand re-oxygenation (p > 0.08) or average hyperemic response (p > 0.09).ConclusionsAlthough women may report blunted sympathetic vasoconstriction than men when assessed separately, the similar sympathetic-mediated restriction of vasodilation suggests a similar dynamic regulation of VC between sexes. SYMP-mediated restrictions of the normal forearm vasodilation do not impair the average hyperemic response and hand re-oxygenation in both sexes.

Project description:BackgroundIt is well-known that methylation changes occur as humans age, however, understanding how age-related changes in DNA methylation vary by sex is lacking. In this study, we characterize the effect of age on DNA methylation in a sex-specific manner and determine if these effects vary by genomic context. We used the Illumina HumanMethylation 450 K array and DNA derived from whole blood for 400 adult participants (189 males and 211 females) from Bangladesh to identify age-associated CpG sites and regions and characterize the location of these age-associated sites with respect to CpG islands (vs. shore, shelf, or open sea) and gene regions (vs. intergenic). We conducted a genome-wide search for age-associated CpG sites (among 423,604 sites) using a reference-free approach to adjust for cell type composition (the R package RefFreeEWAS) and performed an independent replication analysis of age-associated CpGs.ResultsThe number of age-associated CpGs (p < 5 x 10- 8) were 986 among men and 3479 among women of which 2027(63.8%) and 572 (64.1%) replicated (using Bonferroni adjusted p < 1.2 × 10- 5). For both sexes, age-associated CpG sites were more likely to be hyper-methylated with increasing age (compared to hypo-methylated) and were enriched in CpG islands and promoter regions compared with other locations and all CpGs on the array. Although we observed strong correlation between chronological age and previously-developed epigenetic age models (r ≈ 0.8), among our top (based on lowest p-value) age-associated CpG sites only 12 for males and 44 for females are included in these prediction models, and the median chronological age compared to predicted age was 44 vs. 51.7 in males and 45 vs. 52.1 in females.ConclusionsOur results describe genome-wide features of age-related changes in DNA methylation. The observed associations between age and methylation were generally consistent for both sexes, although the associations tended to be stronger among women. Our population may have unique age-related methylation changes that are not captured in the established methylation-based age prediction model we used, which was developed to be non-tissue-specific.

Dataset Information

Remembrances of parental rejection are associated with loneliness as mediated by psychological maladjustment in young Bangladeshi men but not women.

Publications

Remembrances of parental rejection are associated with loneliness as mediated by psychological maladjustment in young Bangladeshi men but not women.

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