Stereoselective Synthesis of Trisubstituted Alkenylboron Reagents by Boron-Wittig Reaction of Ketones.

ABSTRACT: Application of the boron-Wittig reaction to ketone electrophiles provides a straightforward route to trisubstituted alkenylboronic esters. With either a pentamethyldiethylenetriamine or trimethyl-1,4,7-triazacyclononane additive, the olefination can occur with very high levels of stereocontrol and in good chemical yield.

SUBMITTER: Namirembe S 

PROVIDER: S-EPMC7054900 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature