Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.

ABSTRACT:

Background

Olfactory receptor (OR) genes are the largest multi-gene family in the mammalian genome, with 874 in human and 1483 loci in mouse (including pseudogenes). The expansion of the OR gene repertoire has occurred through numerous duplication events followed by diversification, resulting in a large number of highly similar paralogous genes. These characteristics have made the annotation of the complete OR gene repertoire a complex task. Most OR genes have been predicted in silico and are typically annotated as intronless coding sequences.

Results

Here we have developed an expert curation pipeline to analyse and annotate every OR gene in the human and mouse reference genomes. By combining evidence from structural features, evolutionary conservation and experimental data,

SUBMITTER: Barnes IHA 

PROVIDER: S-EPMC7055050 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature