Dysregulation of amino acids and lipids metabolism in schizophrenia with violence.

ABSTRACT:

Background

Many studies have related biochemical characteristics to violence and have reported schizophrenia could elevated the risk of violent behaviour. However, the metabolic characteristics of schizophrenia patients with violence (V.SC) are unclear.

Methods

To explore the metabolic characteristics of schizophrenia with violence and to identify potential biomarkers, untargeted metabolomics was performed by using gas chromatography time-of-flight mass spectrometry to analyse the plasma metabolites of fifty-three V.SC and twenty-four schizophrenia patients without violence (NV.SC). Multivariate and univariate analyses were performed to identify differential metabolites and biomarkers. Violence was assessed by the MacArthur Violence Assessment Study method. Psychiatric sympt

SUBMITTER: Chen X 

PROVIDER: S-EPMC7055102 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature