Quality of life in subjects with upper- and lower-limb spasticity treated with incobotulinumtoxinA.

ABSTRACT:

Background

We evaluated quality of life among subjects with upper- and lower-limb spasticity who received escalating doses of incobotulinumtoxinA (total body doses up to 800 U) in the prospective, single-arm, dose-titration TOWER study.

Methods

In this exploratory trial, subjects (N = 155; 18-80 years of age) with upper- and lower-limb spasticity due to cerebral causes who were deemed to require total body doses of up to 800 U incobotulinumtoxinA received three consecutive injection cycles of incobotulinumtoxinA (400, 600, and up to 800 U), each with 12 to 16 weeks' follow-up. QoL was assessed using the EuroQol 5-dimensions questionnaire, three-level (EQ-5D), before and 4 weeks post-injection in each injection cycle and at the end of injection cycle 3.

Results

The mea

SUBMITTER: Fheodoroff K 

PROVIDER: S-EPMC7055124 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature