Basic Limonoid modulates Chaperone-mediated Proteostasis and dissolve Tau fibrils.

ABSTRACT: The Alzheimer's disease pathology is associated with accumulation of intracellular neurofibrillary tangles and extracellular senile plaques. The formation of initial nucleus triggers conformational changes in Tau and leads to its deposition. Hence, there is a need to eliminate these toxic proteins for proper functioning of neuronal cells. In this aspect, we screened the effect of basic limonoids such as gedunin, epoxyazadiradione, azadirone and azadiradione on inhibiting Tau aggregation as well as disintegration of induced Tau aggregates. It was observed that these basic limonoids effectively prevented aggregates formation by Tau and also exhibited the property of destabilizing matured Tau aggregates. The molecular docking analysis suggests that the basic limonoids interact with hexapeptid

SUBMITTER: Gorantla NV 

PROVIDER: S-EPMC7055235 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature