In vitro and intracellular activities of frog skin temporins against Legionella pneumophila and its eukaryotic hosts.

ABSTRACT: Temporin-SHa (SHa) is a small cationic host defence peptide (HDP) produced in skin secretions of the Sahara frog Pelophylax saharicus. This peptide has a broad-spectrum activity, efficiently targeting bacteria, parasites and viruses. Noticeably, SHa has demonstrated an ability to kill Leishmania infantum parasites (amastigotes) within macrophages. Recently, an analog of SHa with an increased net positive charge, named [K³]SHa, has been designed to improve those activities. SHa and [K³]SHa were both shown to exhibit leishmanicidal activity mainly by permeabilization of cell membranes but could also induce apoptotis-like death. Temporins are usually poorly active against Gram-negative bacteria whereas many of these species are of public health interest. Among them, Legi

SUBMITTER: Crepin A 

PROVIDER: S-EPMC7055270 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature