Lactation stage impacts the glycolytic function of bovine CD4⁺ T cells during ex vivo activation.

ABSTRACT: Dairy cattle undergo dynamic physiological changes over the course of a full lactation into the dry period, which impacts their immunocompetence. During activation, T cells undergo a characteristic rewiring to increase the uptake of glucose and metabolically reprogram to favor aerobic glycolysis over oxidative phosphorylation. To date it remains to be completely elucidated how the altered energetic demands associated with lactation in dairy cows impacts T cell metabolic reprogramming. Thus, in our ex vivo studies we have examined the influence of stage of lactation (early lactation into the dry period) on cellular metabolism in activated bovine CD4⁺ T cells. Results showed higher rates of glycolytic function in activated CD4⁺ T cells from late lactation and dry cows c

SUBMITTER: Eder JM 

PROVIDER: S-EPMC7055328 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature