Immunotherapeutic potential of CD4 and CD8 single-positive T cells in thymic epithelial tumors.

ABSTRACT: Indications for current immune checkpoint inhibitors are expanding and now include thymic epithelial tumors (TETs). Although clinical trials on immune checkpoint inhibitors for TETs are ongoing, a rationale has not yet been established for immunotherapy for TETs. Therefore, we herein performed phenotypic and functional analyses of T cells in surgically resected TET tissues with a focus on the anti-tumor properties of T cells to TETs as a step towards establishing a rationale for immunotherapy for TETs. We examined T-cell profiles in surgically resected TET tissues, particularly CD4 and CD8 single-positive T cells, using flow cytometry. In the functional analysis of T cells in TETs, we investigated not only cytokine production by T cells, but also their cytotoxicity using bispecific T-cell

SUBMITTER: Yamamoto Y 

PROVIDER: S-EPMC7055333 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature