Structure of the MICU1-MICU2 heterodimer provides insights into the gatekeeping threshold shift.

ABSTRACT: Mitochondrial calcium uptake proteins 1 and 2 (MICU1 and MICU2) mediate mitochondrial Ca²⁺ influx via the mitochondrial calcium uniporter (MCU). Its molecular action for Ca²⁺ uptake is tightly controlled by the MICU1-MICU2 heterodimer, which comprises Ca²⁺ sensing proteins which act as gatekeepers at low [Ca²⁺] or facilitators at high [Ca²⁺]. However, the mechanism underlying the regulation of the Ca²⁺ gatekeeping threshold for mitochondrial Ca²⁺ uptake through the MCU by the MICU1-MICU2 heterodimer remains unclear. In this study, we determined the crystal structure of the apo form of the human MICU1-MICU2 heterodimer that functions as the MCU gatekeeper. MICU1 and MICU2 assemble in the face-to-face heterodimer wi

SUBMITTER: Park J 

PROVIDER: S-EPMC7055370 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature