Subcellular localization of FANCD2 is associated with survival in ovarian carcinoma.

ABSTRACT: OBJECTIVE:Ovarian cancer is a leading cause of death from gynecological cancers. Late diagnosis and resistance to therapy results in mortality and effective screening is required for early diagnosis and better treatments. Expression of the Fanconi Anemia complementation group D2 protein (FANCD2) is reduced in ovarian surface epithelial cells (OSE) in patients with ovarian cancer. FANCD2 has been studied for its role in DNA repair; however multiple studies have suggested that FANCD2 has a role outside the nucleus. We sought to determine whether subcellular localization of FANCD2 correlates with patient outcome in ovarian cancer. METHODS:We examined the subcellular localization of FANCD2 in primary OSE cells from consenting patients with ovarian cancer or a normal ovary. Ovarian tissue micro

SUBMITTER: Joshi S 

PROVIDER: S-EPMC7055545 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature