Organizing principles of whole-brain functional connectivity in zebrafish larvae.

ABSTRACT: Network science has begun to reveal the fundamental principles by which large-scale brain networks are organized, including geometric constraints, a balance between segregative and integrative features, and functionally flexible brain areas. However, it remains unknown whether whole-brain networks imaged at the cellular level are organized according to similar principles. Here, we analyze whole-brain functional networks reconstructed from calcium imaging data recorded in larval zebrafish. Our analyses reveal that functional connections are distance-dependent and that networks exhibit hierarchical modular structure and hubs that span module boundaries. We go on to show that spontaneous network structure places constraints on stimulus-evoked reconfigurations of connections and that networks

SUBMITTER: Betzel RF 

PROVIDER: S-EPMC7055648 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature