Dispersion preparation, characterization, and dosimetric analysis of cellulose nano-fibrils and nano-crystals: Implications for cellular toxicological studies.

ABSTRACT: The characterization of cellulose-based nanomaterial (CNM) suspensions in environmental and biological media is impaired because of their high carbon content and anisotropic shape, thus making it difficult to derive structure activity relationships (SAR) in toxicological studies. Here, a standardized method for the dispersion preparation and characterization of cellulose nanofibrils (CNF) and nanocrystals (CNC) in biological and environmental media was developed. Specifically, electron microscopy was utilized and allowed to specify optimum practices for efficiently suspending CNF and CNC in water and cell culture medium. Furthermore, a technique for measuring the in vitro particle kinetics of CNF and CNC suspended in cell culture medium utilizing fluorescently tagged materials was d

SUBMITTER: Bitounis D 

PROVIDER: S-EPMC7055660 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature