In Silico Analysis of Gardnerella Genomospecies Detected in the Setting of Bacterial Vaginosis.

ABSTRACT:

Background

Gardnerella vaginalis is implicated as one of the causative agents of bacterial vaginosis, but it can also be isolated from the vagina of healthy women. Previous efforts to study G. vaginalis identified 4 to 6 clades, but average nucleotide identity analysis indicates that G. vaginalis may be multiple species. Recently, Gardnerella was determined to be 13 genomospecies, with Gardnerella piottii, Gardnerella leopoldii, and Gardnerella swidsinkii delineated as separate species.

Methods

We accessed 103 publicly available genomes annotated as G. vaginalis. We performed comprehensive taxonomic and phylogenomic analysis to quantify the number of species called G. vaginalis, the similarity of their core genes

SUBMITTER: Potter RF 

PROVIDER: S-EPMC7055668 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature