A Physician-Completed Digital Tool for Evaluating Disease Progression (Multiple Sclerosis Progression Discussion Tool): Validation Study.

ABSTRACT: BACKGROUND:Defining the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive multiple sclerosis (SPMS) can be challenging and delayed. A digital tool (MSProDiscuss) was developed to facilitate physician-patient discussion in evaluating early, subtle signs of multiple sclerosis (MS) disease progression representing this transition. OBJECTIVE:This study aimed to determine cut-off values and corresponding sensitivity and specificity for predefined scoring algorithms, with or without including Expanded Disability Status Scale (EDSS) scores, to differentiate between RRMS and SPMS patients and to evaluate psychometric properties. METHODS:Experienced neurologists completed the tool for patients with confirmed RRMS or SPMS and those suspected to be transitioning t

SUBMITTER: Ziemssen T 

PROVIDER: S-EPMC7055760 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature