Association of combination statin and antihypertensive therapy with reduced Alzheimer's disease and related dementia risk.

ABSTRACT:

Background

Hyperlipidemia and hypertension are modifiable risk factors for Alzheimer's disease and related dementias (ADRD). Approximately 25% of adults over age 65 use both antihypertensives (AHTs) and statins for these conditions. While a growing body of evidence found statins and AHTs are independently associated with lower ADRD risk, no evidence exists on simultaneous use for different drug class combinations and ADRD risk. Our primary objective was to compare ADRD risk associated with concurrent use of different combinations of statins and antihypertensives.

Methods

In a retrospective cohort study (2007-2014), we analyzed 694,672 Medicare beneficiaries in the United States (2,017,786 person-years) who concurrently used both statins and AHTs. Using logistic regression ad

SUBMITTER: Barthold D 

PROVIDER: S-EPMC7055882 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature