The life-cycles of skin replacement technologies.

ABSTRACT: INTRODUCTION:Skin Replacement Technologies (SRTs) emerged as skin alternatives for burns, large excisions or trauma. The original publications represent the available knowledge on a subject and can be modeled as a logistic S-curve which depicts the technology's evolution life-cycle. The Technology Innovation Maturation Evaluation (TIME) model was previously introduced to study the life-cycles of biotechnologies. METHODS:PubMed database was searched 1900-2015 to review relevant publications. All skin replacement or regeneration products on the US market were included. The TIME model was applied to assess evolutionary patterns for each technology. RESULTS AND DISCUSSION:Three SRT clusters were identified: processed biologics technologies (PBT), extracellular matrix technologies (EMT), and ce

SUBMITTER: Climov M 

PROVIDER: S-EPMC7055911 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature