A unique feature of swine ANP32A provides susceptibility to avian influenza virus infection in pigs.

ABSTRACT: Both the replication and transcription of the influenza virus are catalyzed by the viral polymerase complex. The polymerases of most avian influenza A viruses have poor performance in mammalian cells, which is considered to be one of the important species barriers. Pigs have been long considered as important intermediate hosts for interspecies transmission of the avian influenza virus, because of their susceptibility to infection with both avian and mammalian influenza viruses. However, the molecular basis of influenza polymerase adaptation in pigs remains largely unknown. ANP32A and ANP32B proteins have been identified as playing fundamental roles in influenza virus replication and host range determination. In this study, we found that swine ANP32A (swANP32A), unlike swine ANP32B or other

SUBMITTER: Zhang H 

PROVIDER: S-EPMC7055917 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature