Cytoskeleton polarity is essential in determining orientational order in basal bodies of multi-ciliated cells.

ABSTRACT: In multi-ciliated cells, directed and synchronous ciliary beating in the apical membrane occurs through appropriate configuration of basal bodies (BBs, roots of cilia). Although it has been experimentally shown that the position and orientation of BBs are coordinated by apical cytoskeletons (CSKs), such as microtubules (MTs), and planar cell polarity (PCP), the underlying mechanism for achieving the patterning of BBs is not yet understood. In this study, we propose that polarity in bundles of apical MTs play a crucial role in the patterning of BBs. First, the necessity of the polarity was discussed by theoretical consideration on the symmetry of the system. The existence of the polarity was investigated by measuring relative angles between the MTs and BBs using published experimental data.

SUBMITTER: Namba T 

PROVIDER: S-EPMC7055923 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature