Phenotype-based probabilistic analysis of heterogeneous responses to cancer drugs and their combination efficacy.

ABSTRACT: Cell-to-cell variability generates subpopulations of drug-tolerant cells that diminish the efficacy of cancer drugs. Efficacious combination therapies are thus needed to block drug-tolerant cells via minimizing the impact of heterogeneity. Probabilistic models such as Bliss independence have been developed to evaluate drug interactions and their combination efficacy based on probabilities of specific actions mediated by drugs individually and in combination. In practice, however, these models are often applied to conventional dose-response curves in which a normalized parameter with a value between zero and one, generally referred to as fraction of cells affected (fa), is used to evaluate the efficacy of drugs and their combined interactions. We use basic probability theory, computer simul

SUBMITTER: Comandante-Lou N 

PROVIDER: S-EPMC7055924 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature