Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke.

ABSTRACT: We aimed to characterize the genetics of endothelial function and how this influences risk for cardiovascular diseases such as ischemic stroke. We integrated genetic data from a study of ultrasound flow-mediated dilatation of brachial artery in adolescents from ALSPAC (Avon Longitudinal Study of Parents and Children; n=5214) with a study of ischemic stroke (MEGASTROKE: n=60 341 cases and 452 969 controls) to identify variants that confer risk of ischemic stroke through altered endothelial function. We identified a variant in PDE3A (Phosphodiesterase 3A), encoding phosphodiesterase 3A, which was associated with flow-mediated dilatation in adolescents (9-12 years of age; β[SE], 0.38 [0.070]; P=3.8×10^-8) and confers risk of ischemic stroke (odds ratio, 1.04 [95% CI, 1

SUBMITTER: Traylor M 

PROVIDER: S-EPMC7055937 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature