The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation.

ABSTRACT: Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day. Proper circadian alignment of feeding behavior is necessary to prevent metabolic disease, and thus it is imperative that molecular players that maintain neuronal coordination of energy homeostasis are identified. Here, we demonstrate that mice lacking the p75 neurotrophin receptor, p75NTR, decrease their feeding and food anticipatory behavior (FAA) in response to daytime, but not nighttime, restricted feeding. These effects lead to increased weight loss, but do not require p75NTR during development. Instead, p75NTR is required for fasting-induced activation of neurons within the arcuate hypothalamus. Indeed, p75NTR speci

SUBMITTER: Podyma B 

PROVIDER: S-EPMC7056271 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature