Effect of Timing and Duration of Statin Exposure on Risk of Hip or Knee Revision Arthroplasty: A Population-based Cohort Study.

ABSTRACT:

Objectives

To determine whether the timing and duration of statin exposure following total hip/knee arthroplasty (THA/TKA) influence the risk of revision arthroplasty.

Methods

Subjects from the Clinical Practice Research Datalink, a large population-based clinical database, who had THA/TKA from 1988 to 2016, were included. Propensity score adjusted Cox regression models were used to determine the association between statin exposure and the risk of revision THA/TKA, (1) at any time, and (2) if first exposed 0-1, 1-5, or > 5 years following THA/TKA. We also investigated the effect of duration of statin exposure (< 1, 1-2, 2-3, 3-4, 4-5, > 5 yrs).

Results

The study included 151,305 participants. There were 65,032 (43%) exposed to statins during followup and 3500 (2.3%) h

SUBMITTER: Cook MJ 

PROVIDER: S-EPMC7056350 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature