Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index.

ABSTRACT: Objectives  The purpose of this study was to evaluate the metabolic pathways activated in the serum of African-American women during late pregnancy that predicted term labor dystocia. Study Design  Matched case-control study ( n  = 97; 48 cases of term labor dystocia and 49 normal labor progression controls) with selection based on body mass index (BMI) at hospital admission and maternal age. Late pregnancy serum samples were analyzed using ultra-high-resolution metabolomics. Differentially expressed metabolic features and pathways between cases experiencing term labor dystocia and normal labor controls were evaluated in the total sample, among women who were obese at the time of labor (BMI ≥ 30 kg/m2), and among women who were not obese. Results  Labor dystocia

SUBMITTER: Carlson NS 

PROVIDER: S-EPMC7056397 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature