Ventricular arrhythmia risk prediction in repaired Tetralogy of Fallot using personalized computational cardiac models.

ABSTRACT:

Background

Adults with repaired tetralogy of Fallot (rTOF) are at increased risk for ventricular tachycardia (VT) due to fibrotic remodeling of the myocardium. However, the current clinical guidelines for VT risk stratification and subsequent implantable cardioverter-defibrillator deployment for primary prevention of sudden cardiac death in rTOF remain inadequate.

Objective

The purpose of this study was to determine the feasibility of using an rTOF-specific virtual-heart approach to identify patients stratified incorrectly as being at low VT risk by current clinical criteria.

Methods

This multicenter retrospective pilot study included 7 adult rTOF patients who were considered low risk for VT based on clinical criteria. Patient-specific computational heart models were

SUBMITTER: Shade JK 

PROVIDER: S-EPMC7056519 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature