Changes in global electrical heterogeneity associated with dofetilide, quinidine, ranolazine, and verapamil.

ABSTRACT:

Background

Electrocardiographic (ECG) markers of antiarrhythmic drug (AAD) activity could be used to optimize efficacy and minimize toxicity. Vectorcardiographic global electrical heterogeneity (GEH) is associated with ventricular arrhythmias and sudden death, but it is unclear how GEH measurements change in response to AADs.

Objective

The purpose of this study was to characterize acute effects of AADs on GEH measurements.

Methods

We analyzed double-blind placebo-controlled trial data from healthy volunteers given 1 dose of placebo, dofetilide, quinidine, ranolazine, or verapamil on subsequent visits. Serial ECGs and plasma drug concentrations were collected. Vectorcardiographic GEH parameters (spatial ventricular gradient [SVG], spatial QRST angle, sum absolute QRST

SUBMITTER: Stabenau HF 

PROVIDER: S-EPMC7056537 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature