Dietary fatty acid oxidation is decreased in non-alcoholic fatty liver disease: A palmitate breath test study.

ABSTRACT:

Background & aim

Hepatic fat excess in non-alcoholic fatty liver disease (NAFLD) reflects an imbalance between fat accumulation and disposal. Conflicting data exist for the role of fatty acid oxidation (FAO), one of the disposal pathways, and have mostly come from the studies delivering fatty acids (FAs) intravenously. Whether FAO of orally provided FAs is affected in NAFLD is unknown.

Methods

We performed a breath test study to measure FAO in subjects with NAFLD and healthy controls. Subjects ingested [1-¹³ C] palmitic acid (PA, 10 mg/kg) in a liquid meal and the rate of ¹³ CO₂ appearance in expired air was measured over 6 hours by a BreathID device (Exalenz) to obtain the cumulative percent dose recovered (CPDR), the total amount of ingeste

SUBMITTER: Naguib G 

PROVIDER: S-EPMC7056545 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature