Ontology highlight
ABSTRACT:
SUBMITTER: Yin N
PROVIDER: S-EPMC7056773 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Neuroscience bulletin 20191012 3
Ganglion cells (RGCs) are the sole output neurons of the retinal circuity. Here, we investigated whether and how dopamine D2 receptors modulate the excitability of dissociated rat RGCs. Application of the selective D2 receptor agonist quinpirole inhibited outward K<sup>+</sup> currents, which were mainly mediated by glybenclamide- and 4-aminopyridine-sensitive channels, but not the tetraethylammonium-sensitive channel. In addition, quinpirole selectively enhanced Nav1.6 voltage-gated Na<sup>+</s ...[more]