A Systematic Review and Meta-Analysis of Depression and Protein-Energy Wasting in Kidney Disease.

ABSTRACT:

Introduction

Depression comorbid with chronic disease may be mediated by inflammation. We sought to characterize relationships between inflammatory biomarkers and depressive symptoms in patients with chronic kidney disease and end-stage kidney disease.

Methods

A systematic literature search was conducted by 2 authors up to March 19, 2019, for studies of patients with chronic kidney disease or end-stage kidney disease evaluating circulating inflammatory biomarkers associated with depression of chronic disease: albumin, C-reactive protein (CRP), high-sensitivity CRP, interleukin-6 (IL-6), tumor necrosis factor-α, and interleukin-1. Standardized mean differences in biomarkers between individuals with and without depression were computed and analyzed using mixed effects models.

SUBMITTER: Gregg LP 

PROVIDER: S-EPMC7056860 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature