APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale.

ABSTRACT:

Introduction

Much of the higher risk for end-stage kidney disease (ESKD) in African American individuals relates to ancestry-specific variation in the apolipoprotein L1 gene (APOL1). Relative to kidneys from European American deceased-donors, kidneys from African American deceased-donors have shorter allograft survival and African American living-kidney donors more often develop ESKD. The National Institutes of Health (NIH)-sponsored APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) is prospectively assessing kidney allograft survival from donors with recent African ancestry based on donor and recipient APOL1 genotypes.

Methods

APOLLO will evaluate outcomes from 2614 deceased kidney donor-recipient pairs, as well as additional living-kidne

SUBMITTER: Freedman BI 

PROVIDER: S-EPMC7056919 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature