Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women.

ABSTRACT:

Background

Obesity has become the main health issue in developed countries as it impacts life expectancy and increases mortality of cerebrovascular or cardiovascular diseases. The leptin is one of the adipokines which presents in the serum in proportion to the amount of adipose tissue and is translated from LEP gene. It involves in energy homeostasis, lipid and glucose metabolisms, modulation of immune systems, and thermogenesis. Many previous studies have revealed controversial results between LEP polymorphisms and leptin levels in different ages and ethnicities. Herein, we investigated the impacts of LEP polymorphism against leptin levels in Taiwanese subjects.

Methods

In 599 Taiwanese subjects, excluding clinically overt systemic disease, age below 18 years old, and C-rea

SUBMITTER: Duan DM 

PROVIDER: S-EPMC7057123 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature