METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m⁶A Modification.

ABSTRACT: N⁶-Methyladenosine (m⁶A) is the most common internal modification of eukaryotic messenger RNA (mRNA) that occurred on the N⁶ nitrogen of adenosine. However, the roles of m⁶A in oral squamous cell carcinoma (OSCC) are still elusive. Here, we investigate the function and mechanism of methyltransferase-like 3 (METTL3) in OSCC tumorigenesis. Clinically, METTL3 was significantly upregulated in tissue samples and correlated with the poor prognosis of OSCC patients. Functionally, loss and gain studies illustrated that METTL3 promoted the proliferation, invasion, and migration of OSCC cells in vitro, and METTL3 knockdown inhibited tumor growth in vivo. Mechanistically, methylated RNA immunoprecipitation sequencing (MeRIP-seq) illustrated that METTL3 targ

SUBMITTER: Zhao W 

PROVIDER: S-EPMC7057159 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature