Evaluation of Association Between Oral and Topical Terbinafine Use in Pregnancy and Risk of Major Malformations and Spontaneous Abortion.

ABSTRACT:

Importance

Terbinafine is a commonly used antifungal agent, but safety data of its use in pregnancy are limited.

Objective

To examine the association between oral and topical terbinafine exposure in pregnancy and the risk of major malformations and spontaneous abortion.

Design, setting, and participants

A nationwide, registry-based cohort study was conducted in Denmark from January 1, 1997, to December 31, 2016, in a cohort of 1 650 649 pregnancies. Data analysis was performed from July 11 to October 20, 2019. Pregnancies were matched on propensity scores comparing oral terbinafine exposed vs unexposed (1:10 ratio), topical terbinafine exposed vs unexposed (1:10), and oral vs topical terbinafine exposed (1:1).

Exposures

Filled prescriptions for oral or topical

SUBMITTER: Andersson NW 

PROVIDER: S-EPMC7057179 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature