Enhanced monoacylglycerol lipolysis by ABHD6 promotes NSCLC pathogenesis.

ABSTRACT:

Background

Tumor cells display metabolic changes that correlate with malignancy, including an elevated hydrolysis of monoacylglycerol (MAG) in various cancer types. However, evidence is absent for the relationship between MAG lipolysis and NSCLC.

Methods

MAG hydrolase activity assay, migration, invasion, proliferation, lipids quantification, and transactivation assays were performed in vitro. Tumor xenograft studies and lung metastasis assays were examined in vivo. The correlations of MAGL/ABHD6 expression in cancerous tissues with the clinicopathological characteristics and survival of NSCLC patients were validated.

Findings

ABHD6 functions as the primary MAG lipase and an oncogene in NSCLC. MAG hydrolase activities were more than 11-fold higher in cancerous lung tis

SUBMITTER: Tang Z 

PROVIDER: S-EPMC7057193 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature