Early-life inhalant allergen exposure, filaggrin genotype, and the development of sensitization from infancy to adolescence.

ABSTRACT:

Background

We hypothesized that filaggrin (FLG) loss-of-function mutations modify the effect of allergen exposure on the development of allergic sensitization.

Objective

We sought to determine whether early-life exposure to inhalant allergens increases the risk of specific sensitization and whether FLG mutations modulate these odds.

Methods

In a population-based birth cohort we measured mite, cat, and dog allergen levels in dust samples collected from homes within the first year of life. Sensitization was assessed at 6 time points between infancy and age 16 years. Genotyping was performed for 6 FLG mutations.

Results

In the longitudinal multivariable model (age 1-16 years), we observed a significant interaction between FLG and Fel d 1 exposure on cat sensitizat

SUBMITTER: Simpson A 

PROVIDER: S-EPMC7057264 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature