Sex and Glomerular Filtration Rate Trajectories in Children.

ABSTRACT:

Background and objectives

Differences in CKD progression by sex have been hypothesized to explain disparities in access to kidney transplantation in children. This study aims to identify distinct trajectories of eGFR decline and to investigate the association of sex with eGFR decline.

Design, setting, participants, & measurements

We used data from the CKD in Children study. Latent class mixed models were used to identify eGFR trajectories and patient characteristics were compared between trajectories. Progression was studied to two outcomes: ESKD (dialysis or transplantation) and a combined outcome of ESKD or 50% eGFR decline from baseline, using multivariable parametric failure time models.

Results

Among 888 patients, 613 with nonglomerular and 275 with glomerular di

SUBMITTER: Bonneric S 

PROVIDER: S-EPMC7057295 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature