Carbamylated Lipoproteins and Progression of Diabetic Kidney Disease.

ABSTRACT:

Background and objectives

Protein carbamylation is a consequence of uremia and carbamylated lipoproteins contribute to atherogenesis in CKD. Proteins can also be carbamylated by a urea-independent mechanism, and whether carbamylated lipoproteins contribute to the progression of CKD has not been investigated.

Design, setting, participants, & measurements

A case-control study was performed to determine whether there were changes in plasma levels of carbamylated lipoproteins in individuals with type 2 diabetes with eGFR >60 ml/min per 1.73 m² compared with a group of age- and sex-matched healthy controls. A cohort of 1320 patients with type 2 diabetes with baseline eGFR ≥30 ml/min per 1.73 m² was longitudinally followed up to evaluate the association betwe

SUBMITTER: Tan KCB 

PROVIDER: S-EPMC7057307 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature