Klotho Gene in Human Salt-Sensitive Hypertension.

ABSTRACT:

Background and objectives

Hypertension is a common aging-related disorder. Salt intake is one of the main environmental factors contributing to the development of hypertension. Transgenic mice with one-half Klotho deficiency displayed a spontaneous BP increase and salt-sensitive hypertension in response to high sodium intake. Usually circulating levels of α-Klotho decrease with age, and this reduction may be stronger in patients with several aging-related diseases. This study aimed at exploring the association of Klotho with salt sensitivity in humans.

Design, setting, participants, & measurements

The role of Klotho polymorphisms and α-Klotho serum levels was evaluated in patients with hypertension who were treatment naive and underwent an acute salt-sensitivit

SUBMITTER: Citterio L 

PROVIDER: S-EPMC7057312 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature