Prevalence of Celiac Disease in Patients With Iron Deficiency Anemia-A Systematic Review With Meta-analysis.

ABSTRACT: BACKGROUND & AIMS:Anemia is common in patients with celiac disease (CD) and a frequent mode of presentation. Guidelines recommend screening patients with iron-deficiency anemia (IDA) for CD. However, the reported prevalence of CD in patients with IDA varies. We performed a systematic review to determine the prevalence of biopsy-verified CD in patients with IDA. METHODS:We performed a systematic review of articles published in PubMed Medline or EMBASE through July 2017 for the term "celiac disease" combined with "anemia" or "iron deficiency." We used fixed-effects inverse variance-weighted models to measure the pooled prevalence of CD. Meta-regression was used to assess subgroup heterogeneity. RESULTS:We identified 18 studies composed of 2998 patients with IDA for inclusion in our analysis.

SUBMITTER: Mahadev S 

PROVIDER: S-EPMC7057414 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature