Gene expression analysis reveals the tipping points during infant brain development for human and chimpanzee.

ABSTRACT:

Background

Postpartum developmental delay has been proposed as an important phenotype of human evolution which contributes to many human-specific features including the increase in brain size and the advanced human-specific cognitive traits. However, the biological processes and molecular functions underlying early brain development still remain poorly understood, especially in human and primates.

Results

In this paper, we comparatively and extensively studied dorsolarteral prefrontal cortex expression data in human and chimpanzee to investigate the critical processes or biological events during early brain development at a molecular level. By using the dynamic network biomarker (DNB) model, we found that there are tipping points around 3 months and 1 month, which are crucia

SUBMITTER: Tang H 

PROVIDER: S-EPMC7057467 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature