How well do elderly patients with major depressive disorder respond to antidepressants: a systematic review and single-group meta-analysis.

ABSTRACT:

Background

Depression is one of the leading causes of the global burden of disease, and it has particularly negative consequences for elderly patients. Antidepressants are the most frequently used treatment. We present the first single-group meta-analysis examining: 1) the response rates of elderly patients to antidepressants, and 2) the determinants of antidepressants response in this population.

Methods

We searched multiple databases for randomized controlled trials on antidepressants in the elderly with major depressive disorder above 65 years (last search: December 2017). Response was defined as 50% improvement on validated rating scales. We extracted response rates from studies and imputed the missing ones with a validated method. Data were pooled in a single-group meta

SUBMITTER: Gutsmiedl K 

PROVIDER: S-EPMC7057600 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature